Hundreds of civilians, mostly in Iran, have been killed by dueling airstrikes despite international pleas for de-escalation.

New targets appear to indicate an expansion of Israel’s war aims beyond the Iranian nuclear facilities that consumed the first days of the conflict.

Israel hit more targets in Tehran and Iranian missiles fired at Israel killed at least 14, as the conflict entered a third day

The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.

The Israel Defense Forces said the air force had launched strikes against missile sites in central Iran, as the Middle East conflict entered a fourth day.

The Israeli military has damaged critical nuclear infrastructure and killed scientists, but Tehran’s most formidable enrichment plant remains.

The Israeli military claims its campaign has eliminated high-value targets, including nine senior scientists, and severely damaged Iran’s nuclear infrastructure. Iranian authorities confirmed damage to four critical buildings at the Isfahan uranium conversion facility,

Israel and Iran have opened a new chapter in their long history of conflict. Israel launched a major attack with strikes early Friday that set off explosions in the Iranian capital of Tehran.

Israel was exploiting its advantage, saying it had taken out dozens of surface-to-air missiles in western Iran and killed the intelligence chief of the Islamic Revoluti