Margaret Qualley is opening up about the long-lasting effects she suffered while filming for 'The Substance.' The actress, who plays Sue in the body horror film, recently shared on the Happy Sad Confused podcast that her skin was damaged for nearly a year after filming wrapped.

The Substance costume designer Emmanuelle Youchnovski revealed in an interview with Next Best Picture that one of Margaret Qualley’s outfits as Sue in the Golden Globe-nominated body horror masterpiece was inspired by the “Houdini” singer, as well as Beyoncé.

The actress recalled what it was like working with prosthetics for her role in the body horror film, which also stars Demi Moore.

In The Substance, Hollywood star Elisabeth Sparkle (Demi Moore) is fired from her aerobics show when she turns 50. This leads her to seek out a drug called The Substance. After taking the drug, Elisabeth births a younger version of herself who she shares a consciousness with - the catch is she has to alternate living as each every seven days.

Margaret Qualley and Demi Moore were both transformed for their roles in 'The Substance.' According to Qualley, it took her "probably a year to recover physically from all of it."

In 'The Substance,' Margaret Qualley wore a mountain of facial prosthetics, which had a detrimental effect on her face.

In The Substance, Margaret Qualley's character turns into an overnight superstar. So naturally, the film's costume director Emmanuelle Youchnovski turned to some real-life idols for inspiration - including Beyoncé and Dua Lipa.

While Margaret Qualley has garnered high praise for her performance in 2024’s The Substance, she has revealed that the extensive amount of prosthetics that were required for the film took a toll on her skin.

Adhesive materials, artificial skin, and layers of heavy makeup used to create these effects can often clog pores