President Donald Trump on Sunday issued a stark warning to Iran against retaliating on U.S. targets in the Middle East while also predicting Israel and Iran would “soon” make a deal to end their escalating conflict.

Explosions have been seen over Tel Aviv and Jerusalem as the country faces yet another barrage of missiles from Iran. It comes after explosions were reported in central Tehran, as attacks continue between Iran and Israel.

Israel had a plan to assassinate Iranian Supreme Leader Ayatollah Ali Khamenei, but President Trump vetoed the operation, according to reports.

Sen. Lindsey Graham told CBS's "Face The Nation" that he urges President Trump to be prepared to join Israel's attack on Iran up to and including "regime change," if a single American is targeted by Iran.

DUBAI — Israel unleashed airstrikes across Iran for a third day Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program, which could provide an offramp, were canceled.

In sweeping attacks that started early Friday, Israel has struck at the regime in Tehran, targeting Iranian nuclear and military assets. The Israeli strikes have killed more than 70 people, including four top security chiefs, and damaged Iran’s main nuclear site at Natanz.

Experts suggest the U.S. has a strategic opportunity to leverage Iran's weakened position for a nuclear deal after Israel's targeted strikes on Iranian nuclear and military sites.